Antibody Drug Discovery Services
Here at RxBiologics, we understand that each drug discovery campaign is unique. We provide comprehensive packages of work with a flexible approach and optimised workflows to deliver bespoke solutions that work for you.
Our Capabilities
Using our in-house expertise, we will work with you to design bespoke programmes with optimised workflows for accelerated progression to clinic. We support biologics drug discovery from early discovery through preclinical phases, making use of both our capabilities and those of RxCelerate.
REAGENT GENERATION
- Licensed mammalian cell line
- Custom antibody and antigen production
- Protein purification and QC
- Transient cell expression (screening/profiling)
LEAD ISOLATION
- High throughput biochemical assay formats (binding/inhibition)
- Flow cytometry cell binding analysis
- Comprehensive sequence analysis
- NGS for in depth interrogation of diversity
Antibody profiling
- ELISA profiling
- Flow cytometry cell binding
- Affinity (SPR)
- Epitope binning (BLI)
- Polyreactivity
- AC-SINS
- Functional assays
- Biophysical analysis
Immune Library Generation
- Custom build of antibody libraries from immune repertoires for standard and domain antibodies
- Integration into our platform drug discovery process to deliver antibodies with desired profiles
Antibody Humanisation AND OPTIMISATION
- Humanisation and deimmunisation within CDR regions
- Implementation of in silico design and display technology approaches for optimal antibody sequences
IN SILICO ANTIBODY ANALYSIS
- Licensed software tools
- Modelling and Structure Prediction
- Developability prediction
- Immunogenicity prediction
- Antibody optimisation
- Humanisation
Antibody Discovery Using the Galaxy® Platform
- License-free open access to our fully human Galaxy® Library
- Screening for antibodies with desired specificity and cross reactivity
- Profiling for functional activity, affinity, epitope and biophysical characteristics
- MOA studies and ‘in vivo’ testing through our parent company RxCelerate